Sendhil Ramamurthy was born in Chicago to a Kannadiga Indian father and a Tamil Indian mother who had emigrated from India. Sendhil Ramamurthy grew up speaking English and Kannada. His parents are physicians. Sendhil Ramamurthy has one sister who is also a physician. He and his sister were raised in San Antonio. There, he went to Keystone School and graduated in 1991. He is the cousin of comedian and film director Jay Chandrasekhar. Ramamurthy is married to actress Olga Sosnovska and the couple have two children, daughter Halina and son Alex.